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Table 8 Information on the function of the C. elegans lysozymes

From: Diversification and adaptive sequence evolution of Caenorhabditislysozymes (Nematoda: Rhabditidae)

Clade

Gene

Expressiona

Immune system

Pathogens

References

   

Up

Down

Up

Down

 

p-lys clade 1

Cel-lys-1

I, ILN, HN

SEK-1, NSY-1, TIR-1, DBL-1

DAF-16

BT, EC, EF, PA, PL, SM

 

[20, 41, 43, 45, 76–80]

 

Cel-lys-2

I

SEK-1, PMK-1§, ELT-2

 

PA, PL

BT

[43, 45, 76–79]

 

Cel-lys-3

  

DAF-16

BT, EC, MN, PA

 

[19, 41, 43, 78, 79]

 

Cel-lys-7

I, LM

DAF-16, DBL-1

 

EF, MN*, SM

PL

[19, 20, 40, 41, 76, 79–81]

 

Cel-lys-8

I, PB, PG

DBL-1, SMA-2, SEK-1, NSY-1, DAF-16

 

MN, SM

 

[19, 20, 40, 42–44, 76, 79, 80]

p-lys clade 2

Cel-lys-4

I

 

SEK-1

EF

 

[43, 76, 77, 79]

 

Cel-lys-5

I

 

PMK-1§

EF

PA

[43, 76, 79]

 

Cel-lys-6

I

   

PA

[43, 76]

 

Cel-lys-10

 

PMK-1§

 

EF, PL

 

[43, 79]

n.a.

Cel-lys-9

      

i-lys

Cel-ilys-1

      
 

Cel-ilys-2

I

  

MN, PL

PA

[19, 45, 76, 79]

 

Cel-ilys-3

I

DAF-16

 

MN#, PL

PA

[19, 40, 45, 77, 79]

 

Cel-ilys-4

  

DAF-16

PA

 

[41, 43]

 

Cel-ilys-5

I

 

DAF-16

 

PA

[41, 43, 77]

  1. The site of expression is given as I, intestines; ILN, the six IL1 and the six IL2 neurons; HN, unidentified head neurons; PB, terminal pharyngeal bulb; PG, pharyngeal gland cells; and LM, L1 muscle cells. Up- or downregulation by immune system components or pathogens is indicated. The regulatory elements of the immune system are denoted with their standard gene names [55]. Pathogens are abbreviated as follows: BT, Cry5 toxin from Bacillus thuringiensis; EC, Erwinia carotovera; EF, Enterococcus faecalis; MN, Microbacterium nematophilum; PA, Pseudomonas aeruginosa; PL, Photorhabdus luminescens; SM, Serratia marcescens. § pmk-1 regulation in a daf-2 mutant background. * Increased susceptibility in KO mutants and after RNAi gene silencing. # Increased susceptibility after RNAi gene silencing.