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Figure 2 | BMC Evolutionary Biology

Figure 2

From: Selection dramatically reduces effective population size in HIV-1 infection

Figure 2

Reduction in N e following a selective replacement with and without mutations in loci L and S. A) The effect of different initial frequencies of the advantageous allele. B) The effect of different selection coefficients. C) The effect of different recombination rates. D) The effect of different mutation rates at locus L. E) The effect of different initial inbreeding coefficients. F) The effect of different census population sizes. Panels A and C-F all assume s = 0.1. Solid lines indicate that the N/N e ratios are based on the inbreeding coefficient F t ; dashed lines indicate that the N/N e ratios are based on the variance effective population sizes estimated from our simulations. In the presence of mutation, the dashed lines indicate the N/N e ratios based on the upper and lower estimates of variance effective populations size. Black lines indicate cases with mutation; grey lines indicate cases without mutation. Unless otherwise specified, the following parameters were used: in the absence of mutation, μ = 0, v = 0, U = 0, N = 107, s = 0.1, A0 = 10-6, r = 0, and F0 = FAA,0 = Faa,0 = FAa,0 = 0.1; in the presence of mutation, μ = 2.5 × 10-5, v = μ/3, U = μ, N = 107, s = 0.1, A0 = 0, r = 0, and F0 = Faa,0 = 1, FAA,0 = FAa,0 = 0.

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