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Figure 3 | BMC Evolutionary Biology

Figure 3

From: Evolution of the CDKN1C-KCNQ1 imprinted domain

Figure 3

Structure of the IGF2 to CDKN1C region. Tammar BAC clones from GenBank (NCBI) were used to derive the tammar sequence (A). A multiple PIP alignment of mouse and tammar sequence against human (B). Conserved regions (red) and regions of homology (green) occur mostly in gene-rich regions (black boxes), but also in the intergenic regions. The KCNQ1OT1 region is highly conserved between mouse and human, but divergent in tammar (indicated by white). IGF2 to CDKN1C in the tammar (C, top), human (C, middle), and mouse (C, bottom). In human and mouse the region includes two imprinted domains regulated the paternally methylated DMR1 and the maternally methylated DMR2 (blue and pink lollipops respectively). Mouse and human regions have been modified from published figures [31, 33, 74, 75]. Gene order is conserved between human, mouse, and tammar. The imprint status of eight of the fourteen genes are conserved between mouse and human (paternally expressed, blue; maternally expressed, pink; biallelic, black). In the tammar, IGF2 and INS are also paternally expressed, while CDKN1C is biallelic. The imprint status of the remaining genes has not been determined (grey). CpG islands and the distribution of repetitive elements are similar between mouse and human and tammar. However, the CpG island associated with DMR2 is absent in the tammar. There are similar numbers of LINE/SINE elements (blue bars) and simple repeats (green) in all species, but fewer DNA elements and LTR elements (pink and purple bars respectively) in the tammar.

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