Figure 4

Predicted protein structures of medaka NITRs. Schematic representation of 24 NITR families in medaka. V = variable Ig domain; I = intermediate Ig domain; TM = transmembrane region; ⊕ = positively charged residue mid-membrane; orange oval-J = prototypic joining-like region; orange oval = J-like variant (see Additional File 7); ITIM = conventional ITIM and itim = conventional ITIM variant (see Additional File 8). (*) = corresponding full-length cDNA; (I) = cytoplasmic exons unidentifiable; other structures are predicted from genomic sequence. Color-coding as in Figure 1.