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Figure 3 | BMC Evolutionary Biology

Figure 3

From: hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

Figure 3

Phylogenetic tree of atypical eukaryotic hsp70 genes. Included are the proteins encoded in the atypical human hsp70 genes (Groups III, IV, and V in Figure 1) and in the hsp70 genes of eighteen other completely sequenced eukaryotic genomes. Sequences from the latter eighteen non-human genomes were identified using as queries human proteins from Groups II, VI, and VII and the SSPA procedure [36]. The tree is rooted by the DnaK sequence (AAC73125.1) from E. coli (DnaK E. coli) and by representatives of typical human Hsp70s (from Groups II, VI, and VII). See legend to Figure 1 and text for details on methods and calculation of bootstrap values. Human proteins are in red. Acronyms in black indicate the eukaryotic genomes in which other hsp70 genes were found, as follows: ANOGA: Anopheles gambiae (Insects); ARATH: Arabidopsis thaliana (Plants); CANGL: Candida glabrata (Fungi); CAEEL: Caenorhabditis elegans (Nematoda); CHICK: Gallus gallus (Birds); CYAME: Cyanidioschyzon merolae (Red alga); DANRE: Danio rerio (Fish); DROME: Drosophila melanogaster (Insects); ENTHI: Entamoeba histolytica (Protists); LEIMA: Leishmania major (Protists); MOUSE: Mus musculus (Mammals); NEUCR: Neurospora crassa (Fungi); SCHPO: Schizosaccharomyces pombe (Fungi); TRYCR: Trypanosoma cruzi (Protists); XENTR: Xenopus tropicalis (Amphibians); YEAST: Saccharomyces caerevisiae (Fungi).

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