Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents

Table 2 Go categories and relative divergence rates (dN/dS) in hominid and murid lineages

Go categories within "biological process"	dN/dS (ω) hominid	dN/dS (ω) murid	p-value
GO: Organelle organization and biogenesis	0.093797	0.136622	0.34
GO: Carbohydrate metabolism	0.094282	0.061524	0.17
GO: Energy pathways	0.095999	0.06409	0.25
GO: Protein transport	0.1000621	0.056915	0.10
GO: Cell organization and biogenesis	0.102521	0.11164	0.75
GO: Cytoskeleton organization and biogenesis	0.106537	0.123027	0.68
GO: Protein biosynthesis	0.10841	0.076408	0.092
GO: Transcription	0.1093033	0.085371	0.49
GO: Cell growth and/or maintenance	0.112558	0.078195	0.02
GO: Cytoplasm organization and biogenesis	0.115938	0.124335	0.80
GO: Catabolism	0.117659	0.107771	0.70
GO: Transport	0.118198	0.076005	0.059
GO: Amino acid and derivative metabolism	0.118466	0.105378	0.64
GO: Protein metabolism	0.118917	0.09077	0.06
GO: Biosynthesis	0.120925	0.09066	0.054
GO: Physiological process	0.12305	0.08881	0.0001
GO: Cell proliferation	0.125543	0.055601	0.03
GO: Metabolism	0.12623	0.0897	0.0001
GO: Nucleobase et al.*	0.128449	0.07981	0.01
GO: Cell cycle	0.137136	0.055177	0.01
GO: Response to stress	0.140927	0.064359	0.03
GO: DNA metabolism	0.154415	0.062976	0.0028
GO: Protein modification	0.170329	0.116675	0.21
GO: Lipid metabolism	0.171853	0.124668	0.17
GO: Biological_process unknown	0.2353	0.17011	0.001
GO: Cell communication	0.2439164	0.159463	0.17

*Nucleobase, nucleoside, nucleotide and nucleic acid metabolism.
Only those categories of biological processes with at least 5 genes in both lineages are listed. The p-value of the test comparing the average dN/dS (ω) ratio between hominid and murid lineages is given for each category (p-value). None of the category showed an accelerated evolution in hominid or rodent, given the average genome difference between lineages.

ISSN: 2730-7182