Table 6 Binding pocket signatures identified in A domain sequences.
Strain | Adenylation domain of McyB1 | Adenylation domain of McyC | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Binding pocket residues | Substrate* | Binding pocket residues | Substrate* | ||||||||||||||||
| Â | 235 | 236 | 239 | 278 | 299 | 301 | 322 | 330 | 331 | Â | 235 | 236 | 239 | 278 | 299 | 301 | 322 | 330 | 331 | Â |
Anabaena | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
N-C 83/1 | D | V | W | F | F | G | L | V | D | Leu, Arg | D | V | W | S | F | G | L | V | D | Arg |
N-C 267/4 | D | V | W | C | F | G | L | V | Y | Hty, Leu, Phe, Hil, Hph | D | V | W | S | F | G | L | V | D | Arg |
N-C 269/2 | D | V | W | C | F | G | L | V | Y | Hty, Leu, Phe, Hil, Hph | D | V | W | C | F | G | L | V | D | Arg |
N-C 269/6 | D | V | W | C | F | G | L | V | Y | Hty, Leu, Phe, Hil, Hph | D | V | W | C | F | G | L | V | D | Arg |
N-C 270/1 | D | V | W | F | F | G | L | V | D | Leu, Arg | D | V | W | S | F | G | L | V | D | Arg |
90 | D | V | W | F | F | G | L | V | D | Leu, Arg | D | V | W | C | F | G | L | V | D | Arg |
1TU44S16 | D | V | W | F | F | G | L | V | D | Leu | D | V | W | C | F | G | L | V | D | Arg |
1TU30S4 | D | V | W | F | F | G | L | V | D | Leu | D | V | W | C | F | G | L | V | D | Arg |
1TU31S9 | D | V | W | F | F | G | L | V | D | Leu | D | V | W | C | F | G | L | V | D | Arg |
202A1/35 | D | V | W | F | F | G | L | V | D | Leu | D | V | W | S | F | G | L | V | D | Arg |
1TU46S11 | D | V | W | F | F | G | L | V | D | Leu | D | V | W | C | F | G | L | V | D | Arg |
202A/41 | D | V | W | F | F | G | L | V | D | Leu | D | V | W | S | F | G | L | V | D | Arg |
0TU33S16 | D | V | W | F | F | G | L | V | D | Leu | D | V | W | C | F | G | L | V | D | Arg |
258 | D | V | W | F | F | G | L | V | D | Leu | D | V | W | C | F | G | L | V | D | Arg |
1TU32S11 | D | V | W | F | F | G | L | V | D | Leu | D | V | W | S | F | G | L | V | D | Arg |
BIR 246 | D | V | W | C | F | G | L | V | Y | Hty, Leu, Hil, Phe, Hph | D | V | W | C | F | G | L | V | D | Arg |
288 | D | V | W | C | F | G | L | V | Y | Hty, Leu, Phe, Hph | D | V | W | S | F | G | L | V | D | Arg |
315 | D | V | W | S | F | G | L | V | Y | Leu, Hty | D | V | W | S | F | G | L | V | D | Arg |
318 | D | V | W | C | F | G | L | V | Y | Hty, Leu | D | V | W | C | F | G | L | V | D | Arg |
66A | D | V | W | S | F | G | L | V | Y | Hph, Hty, Leu | D | V | W | S | F | G | L | V | D | Arg |
18B6 | D | V | W | S | F | G | L | V | D | Arg | D | V | W | S | F | G | L | V | D | Arg |
Microcystis | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
N-C 31 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | D | V | W | T | I | G | A | V | D | Arg |
N-C 57 | D | G | W | T | I | G | A | V | E | Arg | D | V | W | T | I | G | A | V | D | Arg |
N-C 118/2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | D | V | W | T | I | G | A | V | D | Arg |
N-C 140 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | D | V | W | T | I | G | A | V | D | Arg |
N-C 143 | D | G | W | T | I | G | A | V | E | None | D | V | W | T | I | G | A | V | D | Arg |
N-C 160/2 | D | G | W | T | I | G | A | V | E | None | D | V | W | T | I | G | A | V | D | Arg |
N-C 161/1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | D | V | W | T | I | G | A | V | D | Arg |
N-C 169/7 | D | G | W | T | I | G | A | V | E | Arg, Leu | D | V | W | T | I | G | A | V | D | Arg |
N-C 171/10 | D | G | W | T | I | G | A | V | E | Leu, Arg, Tyr | D | V | W | T | I | G | A | V | D | Arg |
N-C 228/1 | D | G | W | T | I | G | A | V | E | Arg, Leu | D | V | W | T | I | G | A | V | D | Arg |
N-C 264 | D | V | W | T | I | G | A | V | D | Arg | D | V | W | T | I | G | A | V | D | Arg |
N-C 324/1 | D | G | W | T | I | G | A | V | E | Arg, Leu | D | V | W | T | I | G | A | V | D | Arg |
N-C 357 | D | G | W | T | I | G | A | V | E | Arg, Leu, Tyr | D | V | W | T | I | G | A | V | D | Arg |
N-C 496 | D | G | W | T | I | G | A | V | E | Tyr | D | V | W | T | I | G | A | V | D | Arg |
AB2002-24 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | D | V | W | T | I | G | A | V | D | Arg |
UV027 | D | V | W | T | I | G | A | V | E | Arg | D | V | W | T | I | G | A | V | D | Arg |
PCC7806 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | D | V | W | T | I | G | A | V | D | Arg |
K-139 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | D | V | W | T | I | G | A | V | D | Arg |
NIES102 | D | G | W | T | I | G | A | V | E | Leu, Arg, Tyr | D | V | W | T | I | G | A | V | D | Arg |
Planktothrix | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
3 | D | A | L | F | F | G | V | V | D | Arg | D | P | W | G | F | G | L | V | D | Arg |
64 | D | A | L | F | F | G | V | V | D | Arg | D | P | W | G | F | G | L | V | D | Arg |
111 | D | A | L | F | F | G | V | V | D | Arg | D | P | W | G | F | G | L | V | D | Arg |
31/1 | D | A | L | F | F | G | L | V | D | Arg, Hty, Leu | D | P | W | G | F | G | L | V | D | Arg |
32 | D | A | L | F | F | G | L | V | D | Arg, Leu | D | P | W | G | F | G | L | V | D | Arg |
39 | D | A | L | F | F | G | L | V | D | Arg, Leu | D | P | W | G | F | G | L | V | D | Arg |
79 | D | A | L | F | F | G | L | V | D | Arg, Leu | D | P | W | G | F | G | L | V | D | Arg |
SAG 6.89 | D | A | L | F | F | G | L | V | D | Arg, Leu | D | P | W | G | F | G | L | V | D | Arg |
N-C 126/8 | D | A | L | F | F | G | L | V | D | Arg, Leu | D | P | W | G | F | G | L | V | D | Arg |
80 | D | A | L | L | F | G | F | V | A | Hty | D | P | W | G | F | G | L | V | N | Arg |
82 | D | A | L | F | F | G | L | V | D | Arg, Hty, Leu | D | P | W | G | F | G | L | V | D | Arg |
108 | D | A | L | F | F | G | L | V | D | Arg, Leu | D | P | W | G | F | G | L | V | D | Arg |
PCC7821 | D | A | L | F | F | G | L | V | D | Arg, Leu | D | P | W | G | F | G | L | V | D | Arg |
CCAP1459/30 | D | A | L | F | F | G | L | V | D | Arg, Leu | D | P | W | G | F | G | L | V | D | Arg |
CCAP1459/11A | D | A | W | F | F | G | L | V | D | Arg | D | P | W | G | F | G | L | V | D | Arg |
CCAP1459/21 | D | A | W | F | F | G | L | V | D | Arg | D | P | W | G | F | G | L | V | D | Arg |
CCAP1460/5 | D | A | L | L | F | G | F | V | A | Hty, Leu | D | P | W | G | F | G | L | V | D | Arg |
CCAP1459/16 | D | A | L | L | F | G | F | V | A | Hty, Leu | D | P | W | G | F | G | L | V | D | Arg |