Figure 2
From: Evolutionary analysis of the highly dynamic CHEK2duplicon in anthropoids
FISH with a CHEK2 fosmid probe from 22q12.1 in anthropoids. (A): Schematic representation of human chromosome 22 with an enlarged view of the analysed CHEK2/TTC28- locus in 22q12.1. All CHEK2 exons and exon 1 of TTC28 are given. Basepair positions for the duplicated region within the chromosome 22 contig NT_011520 are indicated. Localisations of fosmids WI2-1621D20, covering the duplicated region, and WI2-819H21, covering the CHEK2 non-duplicated region are given below. (B) Comparative FISH of fosmid WI2-1621D20 (labelled in red) covering the ancestral duplicated CHEK2 locus in 22q12.1 on human (HSA), chimpanzee (PTR), gorilla (GGO), orangutan (PPY), white-cheeked crested gibbon (NLE), rhesus macaque (MMU), pig-tailed macaque (MNE) and marmoset (CJA) metaphase chromosomes. The great ape chromosomal designations are given according to [65], for NLE according to [67], for MMU, MNE and PHA according to [47] and for CJA according to [66]. White arrows indicate the ancestral CHEK2 locus.