Figure 4
From: Patterns of evolutionary constraints on genes in humans
(A) A cartoon representation of the DNA-binding domain of ZNF228 (green) in contact with DNA (orange). The nonsynonymous SNP (rs2722722, H484Y) is shown in blue. The complex was modelled based on a homologus structure (1MEY, chain C) taken from the Protein Data Bank (B) Summary of information about nonsynonymous SNPs observed in DNA-binding domains of known and putative transcription factors.