The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands

Table 1 Structural classification of the Bet v 1-like superfamily.

Family name	SCOP family	No. of structures^a	Representative structure
			PDB ID	Description	RMSD/no. of aligned residues^b
Bet v 1 family	Pathogenesis-related protein 10 (PR10)-like [SCOP:d.129.3.1]	15	[PDB:1bv1]	Birch pollen allergen Bet v 1; Betula verrucosa (white birch)	0.00/159
START domain	STAR domain [SCOP:d.129.3.2]	3	[PDB:1em2]	STAR-related lipid transport domain of MLN64; Homo sapiens (human)	2.43/108
Ring hydroxylases α-chain	Ring hydroxylating alpha subunit catalytic domain [SCOP:d.129.3.3]	9	[PDB:1o7n]	Naphthalene 1,2-dioxygenase; Pseudomonas putida	2.42/86
Phosphatidylinositol transfer proteins	Phosphatidylinositol transfer protein, PITP [SCOP:d.129.3.4]	4	[PDB:1t27]	Phosphatidylinositol transfer protein alpha; Rattus norvegicus (rat)	2.28/111
AHA1 domain	Aha1 domain [SCOP:d.129.3.5]	8	[PDB:1xfs]	Hypothetical protein NE0264; Nitrosomonas europaea	2.31/115
Polyketide cyclases	Oligoketide cyclase/dehydrase-like [SCOP:d.129.3.6]	2	[PDB:1t17]	Hypothetical protein CC1736; Caulobacter crescentus	2.59/114
SMU440-related	-	1	[PDB:2b79]	Hypothetical protein SMU440; Streptococcus mutans	2.65/132
PA1206-related	-	1	[PDB:2ffs]	Hypothetical protein PA1206; Pseudomonas aeruginosa	2.53/115
Homotrimeric ring hydroxylases	-	2	[PDB:1z01]	2-Oxo-1,2-dihydroquinoline 8-monooxygenase; Pseudomonas putida	2.47/99
CalC-related	-	1	[PDB:1zxf]	Self-sacrificing resistance protein CalC; Micromonospora echinospora	2.93/87
CoxG family	-	2	[PDB:2ns9]	Hypothetical protein APE2225; Aeropyrum pernix	2.53/117

^aNumber of structures of proteins with non-identical sequences in PDB.
^bRoot mean square distance of backbone atoms of all aligned residues and number of aligned residues in a structural alignment with Bet v 1 [PDB:1bv1].

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