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Table 4 Experimentally determined ligands and substrates of members of the Bet v 1-like superfamily.

From: The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands

Ligand

Family

Subfamily, Protein

References

Membrane lipids

   

   phosphatidylcholine

START

phosphatidylcholine transfer protein

[16]

 

PITP

PITP

[20]

   phosphatidylinositol

PITP

PITP

[20]

   ceramide

START

ceramide binding proteins

[15]

   cholesterol

START

STAR

[14]

Plant hormones

   

   brassinosteroids

Bet v 1

PR-10

[13, 35]

   cytokinins

Bet v 1

CSBP (Vigna radiata)

[11]

  

Bet v 1, PR-10c (Betula verrucosa)

[36, 37]

  

UBP34 (Physcomitrella patens)

[38]

Secondary metabolites

   

   flavonoids

Bet v 1

Bet v 1, PR-10c (Betula verrucosa)

[36, 37]

   dopamine + 4-hydroxyphenylacetaldehyde

Bet v 1

(S)-norcoclaurine synthases

[9]

   emodin

Bet v 1

Hyp-1 (Hypericum perforatum)

[39]

   polyketides

Polyketide cyclases

Polyketide cyclases (Streptomyces spp.)

[23]

   enediynes

CalC-related

CalC (Micromonospora echinospora)

[26]

Polycyclic aromatic hydrocarbons

Ring hydroxylases alpha-chain

 

[19]

 

Homotrimeric ring hydroxylases

 

[25]

RNA

Bet v 1

PR-10

[28, 31, 32]