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Figure 4 | BMC Evolutionary Biology

Figure 4

From: Evolution of nonstop, no-go and nonsense-mediated mRNA decay and their termination factor-derived components

Figure 4

Architecture and consensus alignments of the eRF3/Hbs1p family. A) A schematic representation of the domain architecture of eRF3 is shown along with B) an alignment of separate consensus sequences for paralogues of eRF3/Hbs1p families. Sixty percent conservation consensus sequences were calculated using the Python program ConsensusFinder (G. Atkinson). Uppercase letters indicate amino acids conserved in > 60% of all examined sequences, and lowercase letters indicate a common amino acid substitution group conserved in > 60% of the sequences. A '.' denotes a position that is universally present but not conserved in sequence, and gaps are denoted by "-". Domains are indicated above the alignment with lines terminating in arrows. Other family-specific symbols are as follows. Open grey box: E. octocarinatus eRF1 binding sites [62], filled grey boxes: human eRF1 binding site [11], dashed line: S. pombe eRF1 binding site [61]. Secondary structure is indicated below the alignment for S. pombe eRF3 (PDB accession code 1R5B, [65]) and Sulfolobus solfataricus aEF1A (PDB accession code 1JNY, [92]). Striped blocked are disordered regions with undetermined structure. Other structural designations are as in Figure 1.

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