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Figure 8 | BMC Evolutionary Biology

Figure 8

From: Detecting coevolution without phylogenetic trees? Tree-ignorant metrics of coevolution perform as well as tree-aware metrics

Figure 8

Mutual Information coevolutionary signal in the myosin rod. -log(p-values) are presented for each separation of n residues (i, i + n) for n ranging from 1 to 50. Biochemical studies of alpha helices suggest that a statistically significant signal should be detectable at (i, i + 3) and (i, i + 4). Black digits indicate values of n significant at α = 0.05, and red digits indicate values of n significant after Bonferroni adjustment for multiple comparisons, α = 0.001. No alphabet recoding was applied before analysis with Mutual Information. In addition to n = 3 and n = 4, multiples of seven (7,14,21,28,35) have suggestive p-values through n = 35.

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