Figure 2

The roles of paralogs in protein complexes. a) Shaded areas mark a complex, dashed lines connect paralogs. I) Intra-complex paralogs: when both proteins participate in the same complex; ARG transcription complex includes an intra-complex duplication of genes encoding FUN80 and ARGR1 subunits. II) Bi-complex paralogs: two proteins are involved in different protein complexes; two small complexes are shown: zeta DNA polymerase complex (left) and delta DNA polymerase complex (right). Pair REV3/CDC2 are bi-complex paralogs. III) Overhangs: only one of the paralogs constitutes a subunit of a complex, while its homolog does not aggregate with other proteins in a non-transient manner; Vps4p ATPase transport complex. Here, CHM2 protein (a paralog of DID3) represents an overhang. b) Type of duplication and their contribution to protein complexes: left, whole genome duplication (cytoplasmic ribosomal proteins excluded), and right, small scale duplications. On the pie chart, fractions of all paralog pairs are denoted. Protein complex annotations after SGD consortium.