Figure 3

Evolution of bi-complex paralogs. a) Bi-complex paralogs (right) are potentially cases of sub-functionalization (upper route; bi-complex protein becomes bi-complex paralogous pair) neo-functionalization (single protein in which one paralogous copy is added to another complex). b) A possible evolutionary scenario for a gene duplication event involving epsilon DNA Polymerase and CHRAC complexes. Left, proposed pre-duplication relationships between complexes (ancestral DPB3/DLS1 gene is pictured here before its duplication). Right, the map of modules after a DLS1-DPB3 protein duplication (current S. cerevisiae protein complexes) suggests subfunctionalization.