Evolution of mal ABC transporter operons in the Thermococcales and Thermotogales

Table 1 Arrangements of ORFs in the vicinities of the mal1 and mal2 gene clusters in selected species of the Thermotogales. ORFs from different genome sequences are shown here as their best BLASTP hit in the genome sequence of Tt. maritima¹.

	Tt. maritima	Tt. petrophila	Tt. neapolitana	Tt. lettingae	Ts. melanesiensis	F. nodosum
mal1	TM1192	TM0972
	TM1193	TM1044²
	TM1194	TM1190
	TM1195	TM1191
	TM1196	TM1192
	TM1197	TM1193
	TM1198	TM1194	TM0431
	TM1199	TM1195	TM0810	TM1193
	TM1200	TM1200	TM1200	TM1200
	TM1201	TM1201	TM1201	TM1201
	TM1202	TM1202	TM1202	TM1202
	TM1203	TM1203	TM1203	TM1203
	TM1204	TM1204	TM1204	TM1204	TM1578
	TM1205	TM1217	TM1205	TM0372	X
	TM1206	TM1218	TM1206	X	TM1581
	TM1207	TM1219	TM1207	TM0945	TM0009	TM1875
	TM1208	TM1220	TM1208		TM1851	TM1581
	TM1209	TM1221	TM1209		TM1836	TM1836
					TM1203	TM1203
					TM1204	TM1839
mal2	TM1829	TM1681			TM1391
	TM1830	TM1678			X	TM0781
	TM1831²	TM1679			X	X
	TM1832 ²	TM1677²	TM1826		TM1816	X
	TM1833	TM1832 ²	TM1827		TM1416	X
	TM1834	TM1833	TM1828		TM1417	TM1103
	TM1835	TM1834	TM1834			TM0690
	TM1836	TM1835	TM1835
	TM1837	TM1836	TM1836
	TM1838	TM1203	TM1203
	TM1839	TM1839	TM1839
	TM1840	TM1840	TM1840
	TM1841	TM1841(split?)	TM1841
	TM1842	X	TM1842
	TM1843	X	TM1843
	TM1844	TM1844	TM1844
	TM1845	TM1845	TM1845

Bold, transporter ORFs; Italics, has at least one homolog in this region in another genome; X, an ORF with no close BLASTP hits in the Tt. maritima genome sequence.
¹Note that all malF BLASTP searches only hit TM1203 because TM1838 and TM1837 are pseudogenes in the database.
²transposase