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Table 3 Summary of synonymous to non-synonymous nucleotide substitution patterns within SMR family subclasses SMP and SUG.

From: Diversity and evolution of the small multidrug resistance protein family

SMR 1

SMR 2

Sd

Nd

S

N

pS

pN

dS

dN

dS/dN

SMP

mean

57.27

83.94

79.63

220.37

0.72

0.38

1.68

0.55

3.57

Hsa-smr

Tfu-smr

39.12

88.88

85.17

214.83

0.46

0.41

0.71

0.6

1.18

 

Ser-smr

43.12

90.88

85.5

214.5

0.5

0.42

0.84

0.62

1.34

 

Cli-smr

55

86

82.33

217.67

0.67

0.4

1.66

0.56

2.96

 

Fjo-smr

71.88

90.12

77.67

222.33

0.93

0.41

NA

0.58

NA

 

Ssp-emrE

50.25

88.75

84.83

215.17

0.59

0.41

1.17

0.6

1.95

 

Cau-emrE

56

85

82.83

217.17

0.68

0.39

1.74

0.55

3.14

 

Bja-emrE

44.88

86.12

83.5

216.5

0.54

0.4

0.95

0.57

1.67

 

Bme-emrE

55.38

70.62

83.67

216.33

0.66

0.33

1.61

0.43

3.75

 

Bxe-emrE

49.88

77.12

85.5

214.5

0.58

0.36

1.13

0.49

2.30

 

Pae-emrE

46.88

77.12

85.33

214.67

0.55

0.36

0.99

0.49

2.02

 

Eco-emrE

66.5

96.5

79.33

220.67

0.84

0.44

NA

0.66

NA

 

Gsu-emrE

49.88

78.12

84.5

215.5

0.59

0.36

1.16

0.5

2.34

 

I-qacE

65.62

77.38

81.17

218.83

0.81

0.35

NA

0.48

NA

 

PI-qacEΔ1

64.12

85.88

81.67

218.33

0.79

0.39

NA

0.56

NA

 

P-qacF

47.75

79.25

80.83

219.17

0.59

0.36

1.16

0.49

2.35

 

P-qacG

61

89

80.67

219.33

0.76

0.41

NA

0.58

NA

 

P-qacH

71.25

102.75

76.5

223.5

0.93

0.46

NA

0.71

NA

 

P-qacJ

72.88

92.12

78

222

0.93

0.41

NA

0.6

NA

Eco-emrE

Tfu-smr

70.75

98.25

79.5

220.5

0.89

0.45

NA

0.68

NA

 

Ser-smr

67.62

105.38

79.83

220.17

0.85

0.48

NA

0.76

NA

 

Cli-smr

57.5

79.5

76.67

223.33

0.75

0.36

NA

0.48

NA

 

Fjo-smr

52.88

86.12

72

228

0.73

0.38

2.9

0.53

5.53

 

Ssp-emrE

61

104

79.17

220.83

0.77

0.47

NA

0.74

NA

 

Cau-emrE

55.25

85.75

77.17

222.83

0.72

0.38

2.32

0.54

4.30

 

Bja-emrE

63.62

82.38

77.83

222.17

0.82

0.37

NA

0.51

NA

 

Bme-emrE

59.12

75.88

78

222

0.76

0.34

NA

0.46

NA

 

Bxe-emrE

63

74

79.83

220.17

0.79

0.34

NA

0.45

NA

 

Pae-emrE

64.38

85.62

79.67

220.33

0.81

0.39

NA

0.55

NA

 

Gsu-emrE

62.25

69.75

78.83

221.17

0.79

0.32

NA

0.41

NA

 

I-qacE

47.5

84.5

75.5

224.5

0.63

0.38

1.37

0.52

2.62

 

PI-qacEΔ1

47.5

88.5

76

224

0.62

0.4

1.34

0.56

2.39

 

P-qacF

63.75

73.25

75.17

224.83

0.85

0.33

NA

0.43

NA

 

P-qacG

60.12

83.88

75

225

0.8

0.37

NA

0.52

NA

 

P-qacH

52.62

97.38

70.83

229.17

0.74

0.42

3.5

0.63

5.58

 

P-qacJ

53.38

88.62

72.33

227.67

0.74

0.39

3.1

0.55

5.64

SUG

mean

55.11

91.77

78.26

221.74

0.71

0.41

1.83

0.63

3.41

Hla-sugE

Mba-sugE

60.5

73.5

75.83

224.17

0.8

0.33

NA

0.43

NA

 

Tfu-sugE

45.25

75.75

80.83

219.17

0.56

0.35

1.03

0.46

2.22

 

Ser-sugE

39.5

87.5

80.83

219.17

0.49

0.4

0.79

0.57

1.39

 

Cli-sugE

61.25

76.75

78.83

221.17

0.78

0.35

NA

0.47

NA

 

Fjo-SugE

64.75

82.25

75.17

224.83

0.86

0.37

NA

0.5

NA

 

Gvo-sugE

50.38

66.62

80.83

219.17

0.62

0.3

1.33

0.39

3.42

 

Bja-sugE

47.25

74.75

80

220

0.59

0.34

1.16

0.45

2.57

 

Bme-sugE

55.38

79.62

78.5

221.5

0.71

0.36

2.12

0.49

4.33

 

Bxe-sugE

50.25

72.75

80

220

0.63

0.33

1.36

0.44

3.13

 

Pae-sugE1

49.5

82.5

80.83

219.17

0.61

0.38

1.27

0.52

2.43

 

Pae-sugE2

47.12

57.88

82

218

0.57

0.27

1.09

0.33

3.33

 

Eco-sugE

62

66

79.83

220.17

0.78

0.3

NA

0.38

NA

 

Gsu-sugE

51.88

67.12

81.17

218.83

0.64

0.31

1.43

0.39

3.63

 

I-qacE

62.38

109.62

78.5

221.5

0.79

0.49

NA

0.81

NA

 

PI-qacEΔ1

60.12

116.88

79

221

0.76

0.53

NA

0.92

NA

 

P-qacF

48.88

115.12

78.17

221.83

0.63

0.52

1.35

0.88

1.52

 

P-qacG

51.75

116.25

78

222

0.66

0.52

1.62

0.9

1.80

 

P-qacH

70.12

110.88

73.83

226.17

0.95

0.49

NA

0.8

NA

 

P-qacJ

68.75

111.25

75.33

224.67

0.91

0.5

NA

0.81

NA

 

P-Cfr-sugE

62.62

68.38

80.17

219.83

0.78

0.31

NA

0.4

NA

 

I-sugE

56

89

79.83

220.17

0.7

0.4

2.05

0.58

3.54

Eco-sugE

Mba-sugE

61.62

83.38

76

224

0.81

0.37

NA

0.51

NA

 

Tfu-sugE

60.38

76.62

81

219

0.75

0.35

3.82

0.47

8.10

 

Ser-sugE

53.12

78.88

81

219

0.66

0.36

1.56

0.49

3.17

 

Cli-sugE

57.25

65.75

79

221

0.72

0.3

2.54

0.38

6.71

 

Fjo-sugE

57.25

91.75

75.33

224.67

0.76

0.41

NA

0.59

NA

 

Gvo-sugE

60.75

59.25

81

219

0.75

0.27

NA

0.34

NA

 

Bsp-sugE

55

68

80.17

219.83

0.69

0.31

1.85

0.4

4.63

 

Bme-sugE

59.12

60.88

78.67

221.33

0.75

0.28

NA

0.34

NA

 

Bxe-sugE

56.62

56.38

80.17

219.83

0.71

0.26

2.13

0.31

6.80

 

Pae-sugE1

57.75

69.25

81

219

0.71

0.32

2.26

0.41

5.49

 

Pae-sugE2

59.88

46.12

82.17

217.83

0.73

0.21

2.67

0.25

10.74

 

Gsu-sugE

62.75

52.25

81.33

218.67

0.77

0.24

NA

0.29

NA

 

I-qacE

57

102

78.67

221.33

0.72

0.46

2.54

0.71

3.55

 

PI-qacEΔ1

54.5

109.5

79.17

220.83

0.69

0.5

1.87

0.81

2.31

 

P-qacF

56.38

113.62

78.33

221.67

0.72

0.51

2.41

0.86

2.79

 

P-qacG

60.5

99.5

78.17

221.83

0.77

0.45

NA

0.68

NA

 

P-qacH

54.5

120.5

74

226

0.74

0.53

3.01

0.93

3.24

 

P-qacJ

53.25

118.75

75.5

224.5

0.71

0.53

2.12

0.92

2.31

 

P-Cfr-sugE

47.38

26.62

80.33

219.67

0.59

0.12

1.16

0.13

8.75

 

I-sugE

59

98

80

220

0.74

0.45

3.07

0.68

4.54

  1. List of abreviations: Sd is the number of observed synonymous substitutions; Nd is the number of observed non-synonymous substitutions; S is the number of potential synonymous substitutions; N is the number of potential non-synonymous substitutions; pS is the proportion of observed synonymous substitutions; pN is the proportion of observed non-synonymous substitutions; dS is the Jukes-Cantor correction for multiple hits of pS; dN is the Jukes-Cantor correction for multiple hits of pN.
  2. Species are listed according to a three letter species abbreviation followed by the SMR subclass name: Bja Bradyrhizobium japonicum; Bme Brucella melitensis; Bsp Bradyrhizobium sp. ORS278; Bxe Burkholderia xenovorans; Cau Chloroflexus aurantiacus; Cfr Citrobacter freundii; Cli Chlorobium limicola; Fjo Flavobacterium johnsoniae; Gsu Geobacter sulfurreducens; Gvo Gloeobacter violaceus; Hla Halorubrum lacusprofundi; Hsa Halobacterium salinarum; Mba Methanosarcina barkeri; Pae Pseudomonas aeruginosa; Ser Saccharopolyspora erythraea; Ssp Synechococcus sp. RS9917; Tfu Thermobifida fusca; P plasmid encoded; I integron encoded; PI plasmid/integron encoded; NA data not available.