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Figure 2 | BMC Evolutionary Biology

Figure 2

From: Role of accelerated segment switch in exons to alter targeting (ASSET) in the molecular evolution of snake venom proteins

Figure 2

Ribbon model of (a) dendroaspin (PDB ID: 1DRS) and (b) FS2 (PDB ID: 1TFS). In dendroaspin, the segment CFTPRGDMPGPY is shown in magenta, whereas in FS2, the segment CPTAMWPYQTA is shown in green. Side chains of RGD and TAMW, the key residues in their functional motifs are shown. This segment exchange has profound effects on activity: dendroaspin is a potent antiplatelet protein interacting with αIIbβ3, whereas FS2 is a potent blocker of L-type Ca2+ channels.

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