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Table 2 Predicted affection status for the amino acid substitutions from PRLR gene exon 10

From: Divergent evolution in the cytoplasmic domains of PRLR and GHR genes in Artiodactyla

  SIFT PolyPhen
Species prediction score MSC n prediction PSIC± n
European Cattle (Bos taurus)        
P340T tolerated 0.35 3.1 30 benign 0.78 33
E378K affect protein function 0.02 3.12 28 benign 0.88 27
A536V tolerated 0.34 3.1 29 benign 0.41 31
African Cattle (Bos indicus)        
V439M tolerated 0.07 3.1 29 benign 0.39 31
L497R tolerated 0.36 3.1 29 benign 0.13 30
American bison (Bison bison)        
E384K* tolerated 0.06 3.08 27 benign 1.48 23
European bison (Bison bonasus)        
E384K* tolerated 0.06 3.05 29 benign 1.50 22
Q394K* tolerated 0.16 3.05 29 benign 1.21 24
M445V* tolerated 0.42 3.05 28 benign 1.48 22
Sheep (Ovis aries)        
E387K tolerated 0.47 3.05 29 benign 0.57 31
A476T tolerated 0.64 3.05 29 benign 0.10 30
S480R tolerated 0.62 3.05 29 benign 0.24 31
Domestic pig (Sus scrofa)        
L406P tolerated 0.25 3.16 27 benign 0.65 23
D428A tolerated 0.54 3.15 29 benign 0.04 28
A461G tolerated 0.36 3.15 29 benign 1.34 28
K480R tolerated 0.61 3.15 29 benign 0.29 28
M510L tolerated 0.64 3.15 29 benign 1.31 28
G534S tolerated 0.79 3.17 25 benign 0.23 23
G597S tolerated 0.65 3.15 25 benign 0.35 18
A601V tolerated 0.23 3.15 25 benign 0.51 19
  1. * analyses were done using the cytoplasmic part alone, MSC = median sequence conservation, n = number of sequences represent at this position in the protein alignment, ± PSIC score difference