Does negative auto-regulation increase gene duplicability?

Table 2 Duplicability in the transcriptional network of E. coli (excluding LGT candidates)

	Negative auto-regulation	Positive auto-regulation	Dual auto-regulation	No auto-regulation
Family size = 1	7	2	0	9
Family size >1	27 (16)	6 (3)	2 (2)	21 (15)
d	0.69	0.6	1	0.63

The number of transcription factors belonging to gene families of size Family size = 1 (unduplicated) or Family size>1 (duplicated) are given by type of auto-regulatory interaction. This table corresponds to Table 1 but transcription factors with prior evidence for lateral gene transfer (see Methods) have been excluded. No internal comparison is significant at p < 0.05 using Fisher's exact tests.

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