Figure 4

Example of anaerobic adaptation via the acquisition of a locus transferred several times in Actinobacteria. A) Representation of the formate hydrogenase locus (hyc) locus in Nocardiodes sp.. A part of the Noca_4472 gene (pckA) has been duplicated at each side of the hyc locus, suggesting integration of the hyc locus by homologous recombination. B) Representation of the hyc locus in M. avium subsp. hominissuis compared with the corresponding region in the M. avium subsp. avium genome. The presence of a transposase and the split of radC into two pieces suggests integration by transposition of the hyc locus in M. avium subsp. hominissuis. C) Representation of the hyc locus in M. tuberculosis and the corresponding GC% increase. The graphical representation of the GC content, across a 135 Kb DNA sequence, illustrates other HGT elements with GC% decrease, as indicated.