Figure 7
From: Whole genome duplications and expansion of the vertebrate GATA transcription factor gene family
Evolution of GATA4/5/6 chromosomal regions. The evolutionary scenario describes losses and gains of paralogous genes near GATA456 during two rounds of genome duplication. (a) The duplications of the 0R chordate GATA456 paralogon are shown for the three GATA4, 5, and 6 paralogons (the GATA4b paralogon could not be identified). The reconstructed GATA paralogon(s) for the vertebrate ancestor is shown after the 1R genome duplication (light grey box), or the 2R genome duplication events (medium grey box). Paralogs in the 0R vertebrate genome can be strongly inferred when present in both the GATA4/4-ogm paralogon and the GATA2/3 paralogon (represented by diamond); otherwise it is not clear if these genes were translocated independently into the 1R paralogons. (b) Progression from the inferred 2R state of the last common vertebrate ancestor (medium grey box) to the extant amniote or teleost state (dark grey box).). Paralogous gene families include the Oxysterol binding like proteins, (OSBPL1A/OSBPL2), laminins (LAMA3/LAMA4), Cdk5 and Abl enzyme substrates (CABLES1/CABLES2), abhydrolase domain containing proteins (ABHD1/ABHD3), and sox transcription factors (SOX7/SOX18).