Alignment of Daphnia ROR to other ROR sequences. Alignment of Daphnia pulex ROR (Dappu-ROR) with human (Homo sapiens (Hs)) ROR1, fly (Drosophila melanogaster (Dm)) ROR and sea urchin (Strongylocentrotus purpuratus (Sp)) ROR. The SpROR N-terminal does not figure in the alignment for space purposes, it contains an N-terminal extension with an additional Immunoglobulin domain (not shown) that does not align to its counterparts. In the alignment, the immunoglobulin domain on the extracellular side is underlined, while the frizzled Cystein Rich Domain (CRD) is in italics with conserved cysteines highlighted in grey. In the extracytoplasmic part, the kringle domain is highlighted in grey. The transmembrane domain is underlined. In the cytoplasmic tyrosine kinase domain of the protein, the YXXDYY that corresponds to the site of phosphorylation within the TrkB activation domain is highlighted in grey. Potential SH2 binding sites are also highlighted.