Figure 7From: The genome sequence of the protostome Daphnia pulexencodes respective orthologues of a neurotrophin, a Trk and a p75NTR: Evolution of neurotrophin signaling components and related proteins in the bilateriaDaphnia pulex Trk amino acid sequence. Amino acid positions are numbered on the left. The putative signal sequence cleavage site is indicated by an arrowhead. Leucine-rich motifs are in italics and flanking cysteine clusters in bold. Both Ig-like domains are underlined; conserved asparagines with structural roles for ligand binding are in grey and double underlined. The transmembrane region is underlined by a thick line. The first phosphorylation site by cAMP/cGMP-dependent kinase proteins, RYS is shown with a black background, as is the tyrosine responsible for Shc recruitment. Within the tyrosine kinase domain (boxed), the lysine responsible for ATP binding and the second phosphorylation site by cAMP/cGMP-dependent kinase proteins, RKFT, are shown by a black background. The autophosphorylation sequence (DIYSSDYYK) is highlighted in grey and the autophosphorylated tyrosines are shown on a black background. The tyrosine responsible for PLC gamma docking is underlined and in larger font.Back to article page