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Table 1 Proteins implicated in the Notch pathway and their known functions

From: Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

Component type/role Component name and abbreviation
Receptor Notch
Ligands Delta/Jagged
Fucosyltransferase O-fucosyltransferase (O-fut)
Glycosyltransferase Fringe
Cleavage S1 Furin
Cleavage S2 ADAM 17 = TACE
Metalloproteases ADAM 10 = Kuzbanian
Cleavage S3 Presenilin (Pres)
  Nicastrin
γ-secretase complex Anterior Pharynx defective 1 (APH1)
  Presenilin Enhancer 2 (PEN2)
Transcriptional complex CSL (CBF1, Su(H), Lag-1)
  Silencing Mediator of Retinoid and Thyroid receptors
(SMRT)
Targets Hairy Enhancer of Split (HES)
Ligand Neuralized (Neur)
Regulation Mindbomb (Mib)
Receptor Deltex
Regulation NEDD4/Suppressor of Deltex (Su(dx))
  Mastermind (MAM)
  Numb
  Notchless (Nle)
  Strawberry notch (Sno)