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Figure 5 | BMC Evolutionary Biology

Figure 5

From: Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotes

Figure 5

Evolutionary relationships between the major vertebrate-specific orthologous families of the cystatin superfamily. The rooted neighbor-joining tree shows the evolutionary relationships between the major vertebrate-specific orthologous families cystatins C, M and F, kininogens, fetuins A and B, HRGs, spp24s, cathelicidins, latexins and TIG1s. NJ tree represents the bootstrap consensus following 1000 replicates, nodes with confidence values greater than 50% are indicated. The following sequences were used in the reconstruction of the evolutionary relationships among diverse vertebrate orthologous families: cystatins E/M: Bos taurus (AAT46121), Homo sapiens (NP_001314) and Monodelphis domestica (XP_001379474); cystatins C: Homo sapiens (CAA36497), Acipenser transmontanus (DR975381) and Gekko japonicus (EB169380); cystatins F: Gallus gallus (XP_415013), Xenopus tropicalis (AAH88052) and Monodelphis domestica (XP_001382090); kininogens: Xenopus laevis (AAH83002), Gallus gallus (XP_422766) and Homo sapiens (NP_000884); fetuins A: Xenopus tropicalis (NP_001011278), Gallus gallus (XP_422764) and Homo sapiens (BAA22652); fetuins B: Homo sapiens (AAH69820), Monodelphis domestica (XP_001373317) and Gallus gallus (XP_422765); HRGs: Gallus gallus (XP_001233925), Homo sapiens (EAW78183) and platypus (ENSOANP00000001023); spp24s: Gallus gallus (CAD21839), Homo sapiens (NP_008875) and Oncorhynchus mykiss (CAE45341); cathelicidins: Ambystoma tigrinum (CN057800), Bos taurus (NP_777250) and Gallus gallus (AAZ65842); TIG1s: Xenopus laevis (AAH73285), Homo sapiens (EAW78675) and Gallus gallus (NP_989865) and latexins: Xenopus laevis (NP_001088750), Gallus gallus (XP_001233654) and Homo sapiens (AAH05346). Hydra magnipapillata stefin (CV151842) has been used as an outgroup. Six Eutheria-specific CRES orthologous families and rodent-specific CRP1 family have not been included into the analysis, since they originated from the cystatin C.

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