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Figure 1 | BMC Evolutionary Biology

Figure 1

From: Emergence, development and diversification of the TGF-βsignalling pathway within the animal kingdom

Figure 1

Evolution of Smads and TGF- β receptors in Bilateria. The species tree, not-to-scale, displays the phylogenetic relationship between humans and the other species, using the monophyletic Ecdysozoa hypothesis. Each point of divergence (POD) group joins together species which share the same ancestor with the evolutionary line leading to humans. POD nodes are marked by yellow boxes. Please, note that PODs differ in strength of available supporting evidence (shown by the species tree). The gene table, at the bottom, describes the relationship between human Smads or receptors (right column of the table, and the adjacent gene trees) and orthologs in POD groups. POD groups are described in the top row of the table, and linked by discontinuous lines to respective POD nodes on the above-mentioned species tree. Inside the cells of the table: blue lines represent one to one orthology (all species of the POD group); red lines represent one (human) to two or more orthology (at least one species of the POD group). Finally, an empty cell signifies a failure to identify an ortholog within a given POD group.

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