Figure 4
From: Emergence, development and diversification of the TGF-βsignalling pathway within the animal kingdom
Basal metazoan repertoire of Smads. Trichoplax adhaerens (prefix Ta – in blue), Nematostella vectensis (prefix Nv – in green) and fly proteins (Dad, Medea, dSmad2 and Mad) are shown. The Bayesian tree reveals ancestral metazoan duplications (AMD1, 2 and 3) of the hypothetical single primeval common mediator/receptor activated Smad – note high probability values for all the nodes. N. vectensis sequences were retrieved from GenBank: NvSMAD1 (EDO47037), NvSMAD2 (EDO39594), NvSMAD4 (EDO31382), and NvSMAD6 (EDO39628). The tree is rooted using Dad. Branch lengths are shown in red. Node probabilities are shown in black.