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Table 3 TGF-β pathways of Rhabditoid nematodes.

From: Emergence, development and diversification of the TGF-βsignalling pathway within the animal kingdom

  

Caenorhabditis elegans

Caenorhabditis briggsae

   
 

Sub-pathway

genomic location

exon number

Genomic location

exon number

Ks*

Ka

Ka/Ks

LIGANDS

Axon guidance

UNC-129

IV:9005..9003 kbp

5 exons

CBG21741

IV:4144..4151 kbp

5 exons

0.52

0.07

0.13

  

TIG-2

V:4729..4726 kbp

8 exons

CBG08804

V:1854..1850 kbp

6 exons

0.56

0.12

0.21

 

Sma/Mab pathway

DBL-1

V:6757..6760 kbp

8 exons

CBG19011

V:9985..9986 kbp

8 exons

0.34

0.08

0.24

 

dauer

pathway

daf-7

III:811..813 kbp

5 exons

CBG24910

unassigned

5 exons

0.57

0.4

0.7

RECEPTORS

Sma/Mab

pathway

sma-6 (type I)

II:6324..6327 kbp

12 exons

CBG02627

II:8576..8573 kbp

11 exons

0.57

0.15

0.26

 

dauer

pathway

daf-4 (type II)

III:5624..5632 kbp

11 exons

CBG08963

III:3144..3152 kbp

10 exons

0.62

0.38

0.61

  

daf-1 (type I)

IV:132..138 kbp

9 exons

CBG01651

IV:10179..10176 kbp

9 exons

0.63

0.44

0.7

SMADS

Sma/Mab

pathway

sma-2

(overlaps with ZK370.8)

III:8749..8756 kbp

10 exons

CBG06922

(overlaps with 2 other genes on the opposite strand)

III:9128..9114 kbp

7 exons

0.47

0.02

0.04

  

sma-3

III:6863..6860 kbp

12 exons

CBG16541

III:6052..6058 kbp

12 exons

0.51

0.05

0.1

  

sma-4 (short form present)

III:5816..5820 kbp

12 exons

CBG09090

III:2679..2675 kbp

11 exons

0.52

0.13

0.25

 

dauer

pathway

daf-8

I:8587..8584 kbp

6 exons

CBG12513

I:7282..7287 kbp

6 exons

0.63

0.42

0.66

  

daf-14

IV:10253..10255 kbp

5 exons

CBG04415

IV:11282..11277 kbp

7 exons

0.56

0.58

1.04

  

daf-3

X:825..817 kbp

15 exons

CBG08108

X:222..227 kbp

14 exons

0.63

0.4

0.63

  

tag-68

I:10501..10505 kbp

9 exons

CBG02231

I:5999..6001 kbp

9 exons

0.42

0.01

0.02

SKI

dauer

pathway

daf-5

II:14037..14033 kbp

5 exons

CBG20832

II:10836..10831 kbp

6 exons

0.62

0.44

0.71

  1. Comparison of TGF-β ligands, receptors and Smads in C. elegans and C. briggsae reveals conservation of exon number and chromosomal location for both the Sma/Mab and dauer pathways. However, high Ka/Ks ratios for genes of the dauer pathway (underlined) indicate that it evolved faster since the two species diverged. Data retrieved from WormBase (v. WS178).
  2. * modified Nei-Gojobori (p-distance) model with pairwise deletion and assuming transition/transversion ratio of 2.
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BMC Ecology and Evolution

ISSN: 2730-7182

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