Emergence, development and diversification of the TGF-βsignalling pathway within the animal kingdom

Table 4 Receptor-Smad specificity.

Receptor II	Receptor I	R-Smad	Ligand family
AMHR2	ACVR1	Smad1,5,8	AMH
	BMPR1A	Smad1,5,8
	BMPR1B	Smad1,5,8
BMPR2	BMPR1A	Smad1,5,8	BMP2/4/6/7/9/10/13/15
	BMPR1B	Smad1,5,8
	ACVR1	Smad1,5,8
	ACVRL1	Smad1,5,8
	TGFBR1	Smad2,3	GDF9
TGFBR2	TGFBR1	Smad2,3	TGFB1/2/3
ACVR2A	ACVR1	Smad1,5,8	BMP4/5/7/9/10/14/15
	BMPR1A	Smad1,5,8
	BMPR1B	Smad1,5,8
	ACVRL1	Smad1,5,8
	ACVR1B	Smad2,3	Nodal, GDF1/11, ActA/B/AB, InhA/B/C
	ACVR1C	Smad2,3
ACVR2B	ACVR1	Smad1,5,8	BMP4/7/14
	BMPR1A	Smad1,5,8
	BMPR1B	Smad1,5,8
	ACVR1B	Smad2,3	Nodal, GDF1/3/8/11, ActA/B/AB, InhA/B/C
	ACVR1C	Smad2,3
	TGFBR1	Smad2,3

Mammalian TGF-β type II receptors are listed in the first row. Type I receptors which make functional complexes with each type II receptor are then listed, followed by the R-Smads that the type I receptor activates. The ligands activating each receptor-Smad group are then listed in a cumulative fashion.

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