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Table 1 Results of the analyses using the branch-site model A of Yang and Nielsen (2002) on relaxin family orthologues in teleosts.

From: Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, andexpression analysis

Gene Model Foreground branch Parameter dF 2 Δ L Positively selected sites
insl5 A (alt) teleost insl5b p0 = .55, p1 = .3, p2 = .14, ω2 = 1.0 3 0.0 --
  A (ω2 = 1) teleost insl5b p0 = .53, p1 = .28, p2 = .17 2 -- N/A
  A (alt) teleost insl5a p0 = .52, p1 = .28, p2 = .2, ω2 = 1.04 3 1.0 --
  A (ω2 = 1) teleost insl5a p0 = .51, p1 = .27, p2 = .22 2   N/A
rln A (alt) teleost rln p0 = .43, p1 = .56, p2 = 0.0,ω2 3 0.0 --
  A (ω2 = 1)   p0 = .43, p1 = .56, p2 = 0.0 2   N/A
insl3 A (alt) teleost insl3 p0 = 0, p1 = 0, p2 = 1.0, 2= 1.0 3 4.1 6R(.54), 24S(.83), 27V (.97),50M(.87), 54I (.91), 55Q(.64)
  A (ω2 = 1) teleost insl3 p0 = 0, p1 = 0, p2 = 1.0 2 - N/A 7V(.75),13E(.87),21S
  A (alt) mammalian INSL3 p0 = .56, p1 = .21, p2 = .23, ω2 = 41.9 3 4.0 (.95),28K(.92),29R
       (.61),41G(.79)
  A (ω2 = 1) mammalian INSL3 p0 = .6, p1 = .22, p2 = .17 2   N/A
rln3 A (alt) teleost rln3 p0 = 0, p2 = 1.0, ω2 = 999 3 0.48 All sites selected*
  A (ω2 = 1) teleost rln3 p0 = 0, p1 = 0, p2 = 1.0 2   --
  1. For each gene, either teleosts or mammals were used as the foreground branch on which the alternate (alt) hypothesis of positive selection was compared to the null model (ω = 1, fixed). The proportion of sites subject to purifying (p0), nearly neutral (p1) and positive selection (p2) and the estimate of ω (ω2) in the free model are all given as is the Likelihood (L) of the model. The codon positions (using D. rerio as the reference sequence) of the sites estimated to be subject to positive selection are indicated where significant. The null and alternative models are significantly different when 2 Δ L > 3.841. *For rln3, the models were not statistically different.