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Table 1 Testing for consistent within-species and within-lineage variations in nucleotide substitution rates (N: non-synonymous, S: synonymous) of the MHC-DRB molecule at different regions (ABS: contact residues, non-ABS: non-contact residues)

From: Correlated evolution of nucleotide substitution rates and allelic variation in Mhc-DRB lineages of primates

All lineages Species-specific effects Lineage-specific effects
dN, ABS F42,148 = 2.455, P < 0.001 F59,131 = 1.994, P < 0.001
dS, ABS F42,148 = 1.628, P = 0.018 F59,131 = 1.544, P = 0.021
dN, non-ABS F42,148 = 1.450, P = 0.055 F59,131 = 1.490, P = 0.031
dS, non-ABS F42,148 = 1.893, P = 0.003 F59,131 = 2.568, P < 0.001
dN, all sites F42,148 = 2.227, P < 0.001 F59,131 = 1.744, P = 0.005
dS, all sites F42,148 = 1.503, P = 0.040 F59,131 = 1.782, P = 0.003
Only HLA othologous Species-specific effects Lineage-specific effects
dN, ABS F20,34 = 2.260, P = 0.018 F16,38 = 0.798, P = 0.679
dS, ABS F20,34 = 1.632, P = 0.102 F16,38 = 0.360, P = 0.984
dN, non-ABS F20,34 = 2.195, P = 0.021 F16,38 = 1.412, P = 0.188
dS, non-ABS F20,34 = 2.187, P = 0.022 F16,38 = 0.380, P = 0.980
dN, all sites F20,34 = 2.765, P = 0.004 F16,38 = 0.783, P = 0.694
dS, all sites F20,34 = 2.329, P = 0.015 F16,38 = 0.310, P = 0.993
  1. Results form one-way ANOVA, when including all lineages and only human orthologues (i.e. after excluding W lineages).