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Table 5 Evolutionary breakpoint intervals 'co-localizing' with known cancer-associated genes.

From: Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution

Human chromosome Evolutionary breakpoint interval a Cancer-associated genes located within the respective evolutionary breakpoint interval b Species exhibiting the corresponding evolutionary break
  Position of the 5' boundary (Mb) Position of the 3' boundary (Mb)   
1 1.85 2.28 PRKCZ, SKI MDO, GGA
2 230.76 231.4 SP100 BTA, MDO, GGA
3 184.47 184.69 MCF2L2 BTA, MDO
5 112.29 112.88 ZRSR1, MCC MMU, CFA, MDO
6 74.03 74.19 DDX43 RNO, MMU
11 75.60 76.05 C11orf30 BTA
11 93.55 93.92 MRE11A BTA
11 101.61 101.77 BIRC3 BTA
11 110.09 110.84 POU2AF1 GGA
12 56.26 56.62 CDK4 GGA
19 58.70 59.41 TFPT MMU
  1. a: Evolutionary breakpoint intervals are indicated with respect to their position on the orthologous human chromosome.
  2. b: Data on cancer-associated genes were extracted from the Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org.