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Figure 5 | BMC Evolutionary Biology

Figure 5

From: Origin and evolution of the RIG-I like RNA helicase gene family

Figure 5

Multiple alignment (A) and structural modelling (B) of Res III. The domain sequences were predicted by the Pfam HMM programme and aligned using the CLUSTALW programme. The 3-dimensional structures of the domains were generated using the 3D-jigsaw comparative modelling programme and the VAST search programme and visualised by the Cn3D programme (Version 4.1). Identical (*) and similar (:, .) residues are shown below the alignment. The conserved signature "DECH" is boxed. Amino acid position of the domain position is listed in Table 2. Predicted α-helices (green), β-strands (purple or dark blue) and loops (light blue) are marked in both the alignment and the 3D structures respectively.

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