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Table 2 Key structural domains predicted in the Pfam database.

From: Origin and evolution of the RIG-I like RNA helicase gene family

  GenBank Accession number CARD1 CARD2 Res III DExD/H HELICc TFIIS-C
RIG-I        
Human O95786 1–87 104–191 (0.69)   244–420 (7.1e-14) 655–734 (9.2e-15)  
Xenopus ENSXETP00000020202   103–189 (0.43)   303–434 (1.6e-10) 723–785 (1.3e-13)  
Zebrafish ENSDARP00000058175 (partial)   103–186 (3.7)   246–268 (0.019)   
MDA5        
Human Q9BYX4 7–97 115–200 (2.4e-18) 305–493 (3.2e-22)   743–826 (1.1e-20)  
Chicken XP_422031 37–90 (15) 112–198 (7.8e-06) 298–485 (4.8e-20)   717–800 (5.6e-21) 936–944 (0.51)
Xenopus ENSXETP00000028841 12–97 (0.073) 142–198 (0.002) 299–487 (7.7e-20)   719–802 (1.1e-21) 938–946 (8.6)
Fugu ENSTRUP00000003254 10–96 (0.072) 110–196 (3.2e-05) 300–488 (6.4e-15)   711–794 (1.6e-19) 930–939 (1.1)
LGP2        
Human NP_077024     4–178 (1.3e-13) 392–475 (3.3e-21)  
Chicken ENSGALP00000005315    1–116 (4.3e-05)    521–532 (3.7)
Xenopus ENSXETP00000004920    1–173 (1.5e-17)   395–478 (7.8e-24)  
Fugu ENSTRUP00000040150    3–172 (8.5e-19)   396–477 (9.3e-20)  
DICER        
Human NP_803187     45–207 (1.9e-08) 499–556 (7.7e-17)  
Chicken NP_001035555     45–207 (5.1e-10) 499–556 (7.7e-17)  
Xenopus ENSXETP00000050382 (partial)     35–209 (6.9e-06)   
Fugu ENSTRUP00000014961     46–217 (7.3e-06) 499–556 (7.7e-17)  
eIF4A        
Human AAV38682     56–223 (2.5e-63) 291–367 (1.3e-35)  
Chicken NP_989880     57–224 (6.7e-62) 292–368 (6.5e-36)  
Xenopus NP_001085314     56–223 (1.1e-62) 291–367 (6.5e-36)  
Fugu ENSTRUP00000005018     56–223 (5.7e-59) 291–367 (3.6e-36)  
  1. Note: The amino acid position of each domain is listed and the E values against the Pfam database are indicated in parentheses.