Figure 1

Phylogenetic analysis and domain organization of Snail related proteins. The represented tree was constructed by Bayesian inference (BI) and was rooted using the insect CG15269 proteins as outgroup. This tree is based on a multiple alignment that includes the sequence of all zinc fingers, as well as of SNAG, SCRATCH and SLUG domains when present. Red dots highlight important nodes and their associated numbers represent their statistical support values obtained with different methods of phylogenetic reconstruction: first number = bootstrap support in maximum-likelihood (ML) analysis (150 bootstrap replicates); second number = posterior probabilities in BI analysis; third number = bootstrap support in neighbour-joining (NJ) analysis (1000 bootstrap replicates); fourth number = bootstrap support in maximum-parsimony (MP) analysis (200 bootstrap replicates). The asterisk associated with the support in the NJ analysis indicates that in the NJ tree, this node includes the scratch sequence Caenorhabditis CES-1. The three monophyletic groups, snail, scratchA and scratchB are highlighted using a color code also used in Figures 2B and 3: green, snail genes family; dark blue: scratchA genes family; and light blue, scratchB genes family. Domains of the different proteins are schematically represented on the right of their respective names.