Female responses to experimental removal of sexual selection components in Drosophila melanogaster

Table 2 Summary description of the main modules

Module	Size	Tissue	Up	Down	Fitness assoc.	GO terms
1	55	Testes	24 (n.s.)	31 (n.s.)	Yes (0.016)	Additional file 1: Table S1
2	158	Carcass, Head, Eyes, Heart, Fat body, Spermatheca	52 (mixed, <0.001)	106 (up, <0.001)	Yes (<0.001)	Additional file 1: Table S2
3	108	Crop, Mid gut, Hind gut, Heart, Fat body, Spermatheca	42 (mixed, 0.007)	66 (n.s.)	Yes (<0.001)	Additional file 1: Table S3
4	124	Mid gut	33 (mixed, 0.002)	91 (up, <0.001)	Yes (<0.001)	Additional file 1: Table S4
5	129	Ovary	83 (down, <0.001)	46 (n.s.)	Yes (0.006)	Additional file 1: Table S5
6	164	Brain, Ovary	113 (n.s.)	51 (down, 0.002)	Yes (0.014)	Additional file 1: Table S6
7	105	Brain, Eyes, Head, Thoracic ganglion	25 (n.s.)	80 (up, <0.001)	Yes (0.047)	Additional file 1: Table S7

`Size’: Number of significant genes in each module (n > 50). `Tissue’: tissues in which the transcripts in each module are significantly over-expressed compared to the whole body data from [62]. `Up’ (`Down’) is the subset of up-regulated (down-regulated) transcripts in the module. In parentheses is indicated whether the subset tend to be up-regulated or down-regulated after mating, or a mix of the two (mixed); P value from a MR-GSE test; see also Additional file 1: Figures S1A-S7A, data from [44]. `Fitness assoc’. indicates whether the genes in the module are over-represented among the genes found to be associated with female fitness MR-GSE test, data from [60].

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