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Figure 1 | BMC Evolutionary Biology

Figure 1

From: The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates

Figure 1

The structure of murine translation initiation factor 4E (eIF4E-1) with mRNA cap showing key binding residues. The crystal structure of Class I murine eIF4E, [PDB:1L8B], was used to show conserved binding domains. Residues W56, W102, and W166 are highlighted in red, as well as E103, which is highlighted in orange, directly interact with the methyl-guanosine moiety. Residues R112, R157 and K162, which are highlighted, contribute charged interactions with the phosphate bridge that links the m7GTP to the rest of the mRNA chain. A key conserved domain that interacts with eIF4G or eIF4E-interacting proteins is colored green on alpha helix-1.

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