Figure 4

Sequence logos for the core eIF4E domain for all nine core dinoflagellate sub-clades. The alignment and gap arrangement are identical to that used for the phylogeny, although only core dinoflagellates are represented. The positions of the alpha helices and beta sheets of murine Class I eIF4E [PDB:1L8B] are shown using arrows to represent beta sheets and red curves for alpha helices. The cap binding residues and the eIF4G interacting domain are highlighted. The eight conserved aromatic residues are numbered according to the murine reference structure. Specific, conserved amino acids demonstrated to bind the mRNA cap in the murine model are highlighted with grey arrows. The legend for the amino acid coloring is displayed.