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Figure 2 | BMC Evolutionary Biology

Figure 2

From: Comparative functional pan-genome analyses to build connections between genomic dynamics and phenotypic evolution in polycyclic aromatic hydrocarbon metabolism in the genus Mycobacterium

Figure 2

Clustering and pan-genomic change of the 27 fully genome-sequenced mycobacteria. (A) Maximum likelihood tree was constructed by concatenation of the 22 conserved genes in the 27 mycobacteria (available on TreeBASE S16971). The tree was rooted using the free-living M. smegmatis MC2 155, with the largest genome size, as an outgroup. The branches were annotated with bootstrap support. (B) Effect on the pan- and core genome dynamics found by a progressive addition of genomes based on phylogeny. (C) Dichotomous phenotype clustering corresponding to phylogeny for lifestyle, growth rate, pathogenicity, PAH-metabolism, and plasmid content. (D) Functional clustering of the 27 mycobacterial genomes based on COG functions. Green circles and red triangles indicate free-living and host-dependent lifestyles, respectively.

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