Skip to main content

Table 2 The 11 genes experiencing recurrent positive natural selection

From: The effects of natural selection across molecular pathways in Drosophila melanogaster

Gene

n c

D N

D S

P N

P S

P FET

Phenotype(s)

nonC

1852

31

39

8

53

0.000076

Hippo decrease

       

Hedgehog increase

Set2

1408

27

37

17

73

0.001521

Hedgehog increase

Nup153

1294

49

49

8

30

0.001623

Hedgehog decrease

       

RTK-Ras-ERK signaling decrease

       

RTK-Ras-ERK signaling increase

Kib

1076

5

26

0

62

0.003269

Decreased cell viability

pcm

1072

29

28

4

19

0.005061

Blood TE activity

Cnot4

860

20

20

9

34

0.005227

Hippo decrease

ZC3H3

414

9

8

6

31

0.007610

Hippo increase

       

RTK-Ras-ERK signaling decrease

Nup205

781

11

21

2

28

0.007613

Wnt increase

Dref

554

6

20

0

29

0.007942

Hedgehog increase

       

RTK-Ras-ERK signaling decrease

Sik3

571

6

7

4

37

0.008072

Hippo decrease

RasGAP1

979

6

26

1

54

0.009106

Innate immunity

       

RTK-Ras-ERK signaling increase

  1. For each gene, the number of codons analyzed (n c ), the number of nonsynonymous (D N ) and synonymous (D S ) substitutions, the number of nonsynonymous (P N ) and synonymous (P S ) polymorphisms are given along with the P-value for Fisher’s exact test (P FET) and the RNAi knockdown phenotypes affected by the gene