Fig. 8

Schematic representation of PI3K evolutionary history. The eukaryotic tree was built according to Adl et al. [35], Delsuc et al. [87] papers and Lecointre and Le Guyader book [88]. Information about catalytic and regulatory subunits are displayed in orange and dark blue, respectively. Taxonomic group colors are the same as in Fig. 1. Number of protein copies are indicated in the colored circles and the absence of homologs resulting from secondary losses are represented by a dotted circle. The question marks correspond to supposed lack of homologs for taxonomic groups where only one proteome is available in our databases. Duplication events are indicated by a star, losses by a cross and the emergence of regulatory subunit by a vertical line