Fig. 2

Alignments of the molluscan Pax2/5/8 domains and their bilaterian orthologs. a Paired domain alignment of the predicted amino acids of various metazoan Pax genes including Acr-Pax2/5/8, Ntu-Pax2/5/8, and Ino-Pax2/5/8 (highlighted in red). This alignment was used for the maximum-likelihood consensus tree shown in Fig. 3. b Alignment of Pax proteins of various metazoans including Acr-Pax2/5/8, Ntu-Pax2/5/8, and Ino-Pax2/5/8 (highlighted in red). The conserved N-terminal paired domain (red), the octapeptide (blue), and the lysine-arginine-rich region (green) are shown, while the partial homeodomain and the C-terminal transactivation domain are omitted. GenBank accession numbers of all encoding genes used are listed in Table 1