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Table 2 Summary of USP4, USP15 and USP11 interaction partners

From: Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11

Pathway   USP4 Ref. USP15 Ref. USP11 Ref.
RNA splicing Lsm2 +   +   
Lsm4 +   +   
Lsm6 +   +   
Mepce +   +   
Naa38 +   +   
Ppih +   +   
Prp3 + [9] +   
Prp31 +   +   
Prp4 +   +   
Sart3 + [9] + [10]  
Tut1 +   +   
TGF-β signalling Tgfbr1 + [13] + [4] + [12]
Smad7   + [4] + [12]
Smad1   + [4]  
Smad2   + [4]  
Smad3   + [4]  
Smad4   + [4]  
Smurf1   +   
Smurf2   + [4]  
Bmpr1a   + [81]  
Tumor suppression p53    + [16]
Mdm2   + [15]  
Arf-bp1 + [14]   
Brca2    + [18]
Pml    + [17]
Notch1   +   +  
Rb + [82]   
Innate immunity Keap1   + [83] +  
Rig-i + [84]   
Trim25   + [85]  
Trim21 + [86]   
Rip1 + [87]   
Tak1 + [6]   
Traf6 + [7]   
Traf2 + [7]   
Ikka    + [88]
Ikba   + [8] + [89]
Wnt/β-catenin signalling Apc   + [90]  
Nlk + [5]   
Other A2ar + [91]   
Usp7   +   + [92]
  1. Interactors were identified in a mass proteomic analysis by Sowa et al. [2] and those validated by independent, small-scale studies are referenced. Note that these include K48- and K63-linked substrates and possibly non-substrate binding partners. Italicized interactors indicate proteins that have antagonistic roles in the indicated pathway