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Table 1 Prior distributions and description of the parameters used in the simulations

From: Computer simulation of human leukocyte antigen genes supports two main routes of colonization by human populations in East Asia

Parameters Meaning Prior distribution References and/or explanation
T Admixture time between NEA and SEA under two-route models (in generations) 1 to 2,500 Between 0 and 65,000 years (estimation of the spread of modern humans in East Asia [5]), each generation representing 25 years
A Number of initial lineages in the source population 10 to 50 Numbers of HLA−A, −B and −DRB1 lineages vary between 10 and 40 in East Asian samples (from data listed in Additional file 1: Table S1)
N Maximum population density of one deme 0 to 5,000 According to the estimation of hunter-gatherer densities at the end of Paleolithic (0-0.4 individuals per km 2 [18]
m Population migration rate of one deme 0.01 to 0.20 Between 1 % and 20 % of emigration per generation [18]
r Population growth rate of one deme 0.01 to 0.20 According to the estimation of growth rate for Paleolithic populations [18]
s Coefficient of balancing selection 0 to 0.025 Selection rate higher than 2.5 % was tested by preliminary simulations but it never lead to the reproduction of observed data [4042]