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Table 1 Biological functions of different groups of fungal ABC proteins

From: Diversity and evolution of ABC proteins in mycorrhiza-forming fungi

Group

Function

References

ABC-A

Biological function in fungi unknown, but Magnaporthe grisea transporter Abc4 is required for appresoria formation. Mammalian ABC-A transporters are involved in lipid transport and metabolism

[29–31]

ABC-B

full

ABCB1

Export of mating pheromones

[32–34]

ABCB2

Multidrug resistance; a specific group of ABCB transporters in ascomycetes (but not in Agaricomycotina) is associated with the biosynthesis cluster for the hydroxamate-type siderophores and might have a role in their metabolism.

[14, 35–37]

half

ABCB3

Export of the mitochondria-synthesized precursors of iron-sulfur (Fe/S) clusters; localised to the inner membrane of mitochondria

[38, 39]

ABCB4

Heavy-metal resistance; localized to the vacuolar membrane

[40–42]

ABCB5

Transporter of the inner mitochondrial membrane involved in the export of peptides released upon proteolysis by m-AAA protease

[43, 44]

ABCB6

Unknown

 

ABC-C

ABCC1

Vacuolar import of phosphatidylcholine; bile acid transport

[45, 46]

ABCC2

Unknown

 

ABCC3

Unknown

 

ABCC4

Unknown

 

ABCC5

Unknown; often associated with the secondary metabolism gene clusters

[14, 15, 36]

ABCC6

Heavy metal resistance; vacuolar uptake of glutathione conjugates; localized to vacuolar membrane

[42, 47–49]

ABCC7

Drug resistance; heavy metal resistance

[50–52]

ABC-D

ABCD1

Import of long-chain fatty acids into peroxisomes

[53]

ABCD2

Import of long-chain fatty acids into peroxisomes

[53]

ABCD3/4

Unknown

 

ABC-E

Ribosome biogenesis and assembly of translational pre-initiation complexes

[54, 55]

ABC-F

ABCF1

Biogenesis of 40S and 60S ribosomal subunits

[56]

ABCF2

Regulation of mRNA translation; positive regulator of Gcn2p kinase activity

[57]

ABCF3

Unknown

 

ABCF4

mRNA export factor

[58]

ABCF5

Translation elongation factor

[59, 60]

ABC-G

ABCG1-5

Pleiotropic drug resistance; weak organic acid tolerace; export of toxic metabolites, sterol uptake, translocation of membrane phospholipids and quorum sensing

[37, 61]

ABCG6

Unknown

 

ABCG7

Unknown; are characterised by a presence of EGF domain

[14, 15]

ABC-I

ABCI1

Part of the CCR4-NOT transcriptional regulatory complex

[62]

ABCI2

Unknown

 

ABCI3

Unknown

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