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Fig. 1 | BMC Evolutionary Biology

Fig. 1

From: A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels

Fig. 1

a Comparison of the distribution of dN/dS values of homologs with three different orthologous relationships, accordingly one-to-one, one-to-many and many-to-many. The Kruskal-Wallis test was used to determine that the three distributions are significantly different (Kluskal-Wallis chi-squared = 1366, df = 2, p-value = 1.66e-297), and a post hoc analysis (Mann-Whitney test and Bonferroni correction) revealed that all the pairwise comparisons were significantly different. b Comparison of the values of commonly co-expressed genes between equally sized bins of homologs generated according to quartiles of the corresponding dN/dS values. The black boxes represent the entire set of homologs, while the grey boxes represent the subset of homologs with one to one relationship only. The range of dN/dS values on the x-axis are indicative for both sets of data, they were obtained summing and then averaging corresponding quartiles. The choice of four bins was arbitrary but equal trends were obtained by dividing the value in 10 bins (data not shown) or from a linear regression line fitted to the data (Additional file 2: Figure S1)

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