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Table 1 DAVID analysis of the top and bottom 5 % of homologous human genes ranked by the number of CCG

From: A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels

Homologs with conserved connectivity

Enrichment score

Functional annotation

Benjamini

33.66

Signal peptide

1.22E-36

glycoprotein

2.32E-35

disulfide bond

3.56E-27

27.85

Cell adhesion

5.67E-27

19.52

Extracellular matrix

5.75E-18

10.95

Response to wounding

1.84E-12

defense response

4.18E-08

9.40

Basement membrane

7.21E-07

8.78

glycosaminoglycan binding

2.06E-08

polysaccharide binding

2.68E-08

8.27

plasma membrane part

6.18E-13

8.03

topological domain: Extracellular

3.45E-12

6.98

Immunoglobulin domain

1.47E-13

6.75

Cell motion

1.29E-07

6.29

Chemotaxis

7.33E-06

6.27

EGF-like region, conserved site

1.46E-09

4.26

Hydroxylysine

2.82E-09

Collagen triple helix repeat

6.18E-06

4.09

Cytoskeletal protein binding

2.10E-04

Homologs with diverged connectivity

Enrichment score

Functional annotation

Benjamini

7.09

Zinc finger, C2H2-like

2.30E-10

DNA binding

2.00E-05

Transcription

4.99E-05

6.48

sensory perception of chemical stimulus

4.00E-13

olfactory receptor activity

2.57E-11

4.24

Mammalian taste receptor

2.16E-05

  1. In the table are reported the key components selected from functional clusters that obtained an enrichment score greater than or equal to 4 (see Additional file 3 for the full results)