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Table 1 DAVID analysis of the top and bottom 5 % of homologous human genes ranked by the number of CCG

From: A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels

Homologs with conserved connectivity
Enrichment score Functional annotation Benjamini
33.66 Signal peptide 1.22E-36
glycoprotein 2.32E-35
disulfide bond 3.56E-27
27.85 Cell adhesion 5.67E-27
19.52 Extracellular matrix 5.75E-18
10.95 Response to wounding 1.84E-12
defense response 4.18E-08
9.40 Basement membrane 7.21E-07
8.78 glycosaminoglycan binding 2.06E-08
polysaccharide binding 2.68E-08
8.27 plasma membrane part 6.18E-13
8.03 topological domain: Extracellular 3.45E-12
6.98 Immunoglobulin domain 1.47E-13
6.75 Cell motion 1.29E-07
6.29 Chemotaxis 7.33E-06
6.27 EGF-like region, conserved site 1.46E-09
4.26 Hydroxylysine 2.82E-09
Collagen triple helix repeat 6.18E-06
4.09 Cytoskeletal protein binding 2.10E-04
Homologs with diverged connectivity
Enrichment score Functional annotation Benjamini
7.09 Zinc finger, C2H2-like 2.30E-10
DNA binding 2.00E-05
Transcription 4.99E-05
6.48 sensory perception of chemical stimulus 4.00E-13
olfactory receptor activity 2.57E-11
4.24 Mammalian taste receptor 2.16E-05
  1. In the table are reported the key components selected from functional clusters that obtained an enrichment score greater than or equal to 4 (see Additional file 3 for the full results)