Fig. 1

a Schematic representation of TEV genome, indicating the two non-coding regions and the 11 cistrons. The arrows indicate the proteolytic positions targeted by the corresponding proteases (P1, HC-Pro and NIaPro). b Minimum free energy structure for the WT TEV 5’ UTR. SHAPE probing data (reactivity) is represented with red, yellow or black colors at each nucleotide position. Red arrows point to nucleotides that have been mutagenized in this study, with indication of the mutant nucleotide. SL1, SL2 and SL3 indicate the three stem-loops defining the IRES