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Table 1 Enriched gene ontologies (GO) on extended haplotype block outliers for two categories of differentiated SNPs: unique among laboratory strains (lab-specific) or higher in allele frequency in the lab (Fst*lab>wild)

From: Genomic signatures of domestication on neurogenetic genes in Drosophila melanogaster

SNP Type GO: Biological Process GO: ID # of Genes in GOa **P-value Count
Lab-specific regulation of cellular component size 32535 305 0.028412 8
Lab-specific regulation of biological quality 65008 1994 0.038348 23
Lab-specific generation of neurons 48699 992 0.039188 22
Lab-specific nervous system development 7399 1744 0.040839 32
Lab-specific neurogenesis 22008 1525 0.041256 30
Lab-specific regulation of anatomical structure size 90066 374 0.042371 10
Lab-specific regulation of cell size 8361 89 0.042507 6
Lab-specific cellular component organization 16043 5855 0.042708 43
Lab-specific proboscis extension reflex 7637 9 0.043535 3
Lab-specific reflex 60004 9 0.043535 3
Lab-specific cell differentiation 30154 2770 0.043641 41
Lab-specific regulation of cell morphogenesis 22604 184 0.044224 9
Lab-specific axon development 61564 341 0.047764 12
Lab-specific behavioral response to nutrient 51780 10 0.048507 3
Fst*lab>wild motor neuron axon guidance 8045 62 0.007739 9
Fst*lab>wild system development 48731 2850 0.00912 88
Fst*lab>wild post-embryonic organ development 48569 583 0.009155 29
Fst*lab>wild multicellular organismal development 7275 3977 0.009225 106
Fst*lab>wild biological regulation 65007 13920 0.009452 112
Fst*lab>wild single-organism cellular process 44763 23874 0.014023 162
Fst*lab>wild regulation of biological process 50789 13269 0.015888 106
Fst*lab>wild regulation of cellular process 50794 12824 0.023125 96
Fst*lab>wild single-multicellular organism process 44707 5981 0.024058 118
Fst*lab>wild post-embryonic appendage morphogenesis 35120 452 0.026085 24
Fst*lab>wild appendage development 48736 470 0.026896 24
  1. aNumber of genes from Gene Ontology (Biological Process) from FlyBase FB2015_05
  2. **P-value calculated using Benjamini-Hochberg correction
  3. Gene ontologies within each SNP type are ranked by P-value. No significant gene ontology class was found for haplotypes classified for significantly differentiated SNPs in which the derived SNP is found in lower frequency in the wild (i.e., Fst*wild>lab)